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Cellular Assay Development (Principal Scientist Level) at Jnana Therapeutics
Boston, MA, US

Jnana Therapeutics is an exciting new startup focused on drugging the SLC family of metabolite transporters using a novel drug discovery platform. The company is focused on gut and immunometabolism, as well as lysosomal and mitochondrial function – important disease pathways where SLC transporters provide novel targets for inflammatory disorders, immuno-oncology, and neurological diseases.


At Jnana, we are passionate about leaving a legacy of healthy people, who as a result of breakthrough medicines lead transformed lives. We are building a company committed to innovative science, rigorous drug development, and a constant appreciation for the privilege to serve society by developing medicines. A bold team empowered to perform beyond traditional roles is at the center of all we do. We are seeking individuals who are inspired by this vision.


Role:


The successful candidate with cellular assay development experience and expertise will help guide research efforts with biology colleagues to establish a suite of cellular assays.  This role requires a self-starter with a Pharma or Biotech track record working in various disease area discovery projects, guiding assay design, development and optimization.  A deep knowledge of biochemistry, molecular biology, and/or cell biology along with current assay platforms applied to both medium and high throughput screening, will enable you to guide our team and help establish our platform biology for a broad portfolio of projects in multiple disease areas including neurology, immune-mediated disorders, and Immuno-oncology.


Responsibilities: 




  • Responsibility for the design, development, validation, and optimization of a variety of cell-based assays, including those involving membrane protein transport and binding




  • Proficiency with assay design with a variety of cell types including neuronal, immune, and epithelial cells




  • Using excellent scientific and personal communication skills to work cross-functionally internally and externally with CRO partners 




  • Presentation of results to the team, leadership, and Board members regularly with full transparency




  • Investigation of the scientific literature and application of external knowledge to internal drug discovery programs when appropriate




 Qualifications and Skills:




  • Ph.D. in Biochemistry, Molecular or Cellular Biology with 7+ years of industry success in drug discovery




  • Expertise with in vitro cell-assay design, troubleshooting, and optimization required 




  • Experience with membrane protein (e.g. GPCR, ion channel, SLC or ABC transporters) assays would be ideal




  • An innate ability to take on novel challenges and provide creative solutions to teams across the portfolio




  • Collaborative researcher with strong teamworking skills




  • Desire to contribute insights outside of core expertise




  • Ability to adapt to frequent change and thrive in a dynamic and entrepreneurial early-stage environment