Oncology translational scientist at Repare Therapeutics
Montreal, CA / Quebec, CA

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (  Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly stratified patient populations.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a highly motivated, independent and experienced oncology translational scientist who would like to get in early and grow with the company. As a founding member of the Translational Science team, the successful candidate will significantly impact the design and execution of translational strategies on assets in early stages of drug discovery and development, including indication selection, developing and implementing biomarker strategies, and delivering fit-for-purpose, clinical biomarker assays for clinical trials.

Job title will depend on the experience of the candidate.



  • Develop indication selection and translational science strategies for lead assets in close collaboration with discovery and clinical teams
  • Partners with discovery team to lead, plan, and execute activities at CROs or academic collaborators to deliver key experimental studies that identify biomarkers for mechanism of action/resistance, target engagement, patient stratification, as well as early signs of efficacy (e.g., ctDNA)
  • Lead development and validation of fit-for-purpose pharmacodynamic and patient selection assays for incorporation into clinical trials
  • Work with clinical operations team to deploy biomarker assays to clinical sites/CROs prior to clinical trials and manage execution of assays and logistics of clinical sample handling during clinical trials
  • Interpret biomarker-related results emerging from tumors, assay development and clinical trials, communicating key findings internally and externally
  • Author biomarker sections and contribute to the generation of regulatory documents (e.g., IB, IND, clinical protocols, study reports)
  • Monitor emerging technologies and pilot new technologies for potential clinical utility in collaboration with discovery biology and clinical teams
  • Establish biobank of human tissues to support indication selection, assessment of biomarker variability, and assay validation




  • PhD in molecular oncology, molecular/cell biology, biochemistry, or genomics with relevant post-doctoral training
  • 3+ years industry experience in an oncology translational science role (biomarker identification and assay development, etc.)
  • Deep knowledge in tumor biology and DNA repair pathways


Expert understanding of biomarker assay platforms (e.g. IHC, NGS, qPCR) and their applications in clinical trials