Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.
We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds. The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.
- The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
- To identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
- To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo.
- To develop pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
- To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
- To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window.
- To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
- To maintain detailed laboratory notes and protocols.
- The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.
- MSc or PhD in biological sciences and minimum of 3 years relevant experience.
- Experience in oncology, DNA repair and/or chromatin remodelling is essential.
- A strong background in cell biology and quantitative cell-based assay development using various modalities is essential.
- Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential.
- Experience in pre-clinical drug discovery in an industrial setting is an asset.
- Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is an asset.
- Experience with pharmacodynamic modelling software is an asset.
- Ability to communicate in an open, clear, timely and consistent manner.
- Outstanding organizational skills (lab book, experimental design, documentation etc.).
- Ability to handle multiple projects and utilize judgement to prioritize tasks.
- Ability to contribute as a team member in a dynamic, fast-paced biotech environment.