BlueRock Therapeutics is a cutting-edge cell therapy company at the confluence of pluripotent cell biology and genome engineering, and is focused on three therapeutic areas: Cardiology, Neurology and Immunology. The BlueRock platform combines the power of both cell and gene engineering to develop therapeutics based on the use of pluripotent stem cell banks which have been engineered for allogeneic use and for augmented function.
BlueRock is building an R & D team in Cambridge MA focused on genome engineering of pluripotent stem cells and immune cells. The Genome Engineering Research team will encompass mastery of gene editing techniques, development of a gene circuitry and synthetic biology toolbox, advance analytical tools, and collaboration with the Genome Engineering Process Development team to support process development and cGMP genome engineering. This team is expected to create the industry leading genome engineering platform by innovative internal discovery and external alliance partnerships.
BlueRock`s ambition is to have an R&D team of dynamic and highly engaged and inspired top scientists in one of the most rapidly growing scientific fields of cell therapy. At BlueRock we value open communication, collaboration and a positive and fun working environment in which both individual and team contributions are recognized. Our world-class management team is committed to fostering the growth and career development of employees.
The Research Associate, Genome Engineering Research is a key technical and scientific contributor in an innovative team pioneering the generation of therapeutic cells from pluripotent stem cells. The individual will be responsible for the execution of a variety of genetic modifications to enhance cellular function, including implementation of synthetic biology gene circuits and editing of the immunogenic profile of the cell for optimal therapeutic potency. Responsibilities will include use of gene editing methods (CRISPR/Cas9, TALEN, HDR, etc.) to establish cell lines for BlueRock’s research pipeline that are altered in their genome to provide novel functions or show novel behavior.
This position will report to leadership of the Genome Engineering Research team and:
- Execute in vitro experiments to engineer and characterize pluripotent stem cells and their derivatives.
- Assist in the design and construction of plasmids and RNA for genetic modification
- Apply gene editing technologies including CRISPR/Cas9 in human induced pluripotent stem cells.
- Develop and perform DNA/RNA-based, cell-based, flow cytometric, immunofluorescence and other analytical assays as required.
- Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
- Be responsible for data generation, collection, interpretation and communication of results.
- Prepare and follow standard operating procedures, batch records and other process documentation.
- Attend and present scientific data to colleagues at internal meetings
- BSc with 1 – 5+ years of postdoctoral or equivalent experience.
- Strong background in contemporary molecular and cellular biology with direct experience in gene editing and genome engineering
- Hands-on and technology expertise in pluripotent stem cell biology and differentiation protocols highly valuable
- Effective communicator with excellent organizational skills
- Ability to champion and advance innovative concepts.
- Strong verbal and written communication skills.
- Team player with a ‘can-do’ attitude
Equal Opportunity Workplace: At BlueRock, we welcome and support differences and diversity and we are proud to be an equal opportunity workplace. Please let us know if you require disability-related accommodation or other grounds protected by human rights legislation during the recruitment process so that we can work with you to meet your needs.