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Senior Scientist, Translational Bioinformatics and Biomarker Development at Pandion Therapeutics
Cambridge, MA, US

Pandion Therapeutics is an exciting new company based in Cambridge MA, focused on drug discovery and development in autoimmunity and inflammation. We are seeking a highly motivated Senior Scientist to support biomarker development efforts focusing on Pandion`s autoimmunity pipeline. The successful candidate will apply advanced data analysis skills in collaboration with a group of biomarker scientists to perform translational research and execute on predictive and pharmacodynamic biomarker strategies for programs in pre-clinical and clinical development.

 

RESPONSIBILITIES:

  • Drive application of advanced analytic techniques, including systems biology tools, to extract disease biology insights and identify biological targets from large clinic-genomic biomarker datasets
  • Perform multivariate analysis of omics data
  • Assess and validate new biomarker technologies
  • Support development and execution on lead and exploratory biomarker strategies for multiple drug development projects
  • Effectively manage internal and external scientific collaborations and CROs
  • Participate and thrive in an interactive, team-oriented culture

 

KNOWLEDGE AND SKILL REQUIREMENTS:

Outstanding statistical and bioinformatics programming skills (using R, Python, OmicSoft, Genomics, Perl)

  • Hands-on experience with data processing and analysis, statistical interference techniques, multivariate analysis
  • Experience with establishing and validating links between phenotype and biomarker measurements, such as proteomics, genomics and imaging data
  • Proven experience analyzing and interpreting integrated, high throughput genomic data, including whole exome, whole transcriptome, and single cell next generation sequencing
  • Knowledge and understanding of current methods used to assess disease biology in clinical settings and experience with publicly available molecular biology data sets
  • Experience in clinical drug development is beneficial, including understanding of clinical development functions, e.g., biomarker development, clinical pharmacology and biostatistics
  • Familiarity with machine learning would be highly advantageous
  • Excellent communication, collaboration and influencing skills are required

 

EDUCATION AND EXPERIENCE: 

  • A PhD degree in bioinformatics/biomedical engineering/genetics and genomics or related fields is required
  • 5+ years of postdoctoral experience in basic or translational research, desirably in immunology-related field
  • Experience working in biotech/industry settings is highly preferable

 

ABOUT PANDION

 

Pandion Therapeutics was founded in 2017 with the mission to develop bispecific antibody therapeutics that act at the local site of disease, offering the potential for significantly improved therapeutic options beyond systemic immunosuppressive treatments  We aim to shift the paradigm and create a new generation of drugs with transformative efficacy and improved safety to treat immune-related conditions such as inflammatory bowel disease, type 1 diabetes, and autoimmune liver, kidney and skin diseases.   Pandion was recently recognized as a 2018 Fierce 15 Winner.

 

Pandion Therapeutics is committed to diversity, and proud to be an equal opportunity employer. All qualified candidates will be considered for employment, regardless of race, color, age, ancestry, religion, national origin, gender, gender identity, genetic information, parental or pregnancy status, sexual orientation, citizenship, marital status, disability, or Veteran status.