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Head of Structural Proteomics and Computational Sciences at Black Diamond Therapeutics
New York City, NY, US / Cambridge, MA, US

Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company’s proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.

Responsibilities

  • Lead computational innovation underlying the Black Diamond MAP platform
  • Define, shape and build computational MAP platform to deliver novel, unactioned, allosteric mutant oncogene targets
  • Direct multi-disciplinary, multi-site, team of scientists in the areas of structural proteomics, computational chemistry and bioinformatics.
  • Advance the computational platform, drawing on your strong awareness of the broader field to expand and improve into new scientific areas and through increased computational performance
  • Provide strategic input to senior leadership with regard to shaping BDTX’s broader precision medicine pipeline
  • As a member of the Research Leadership Team, contribute to the development and refining of the overall strategy and vision

 

Qualifications

  • PhD in structural biology, computational chemistry or related scientific field and a knowledge of genomics and bioinformatics
  • Knowledge of protein structure, dynamics and use of modeling to interrogate
  • 10+ years in protein modeling and structural work in a pharmaceutical and/or biotech environment
  • Experience in oncology; Additional therapeutic areas ideal
  • Experience in the successful application of structure-based drug design directly leading to drug candidates
  • Exceptional communication and presentation skills – ability to successfully explain and convey complex computational topics to broader scientific teams
  • Experience directly leading and managing teams

Work Environment:

This job operates in a professional office environment. This role routinely uses standard office equipment.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.