Principal Scientist, DMPK at Black Diamond Therapeutics
Cambridge,, OH, US

Black Diamond Therapeutics is a next-wave cancer precision medicine company. Black Diamond pioneered the development of selective medicines for patients with genetically defined cancers driven by oncogenes activated by allosteric mutations. Using its mutation, allostery and pharmacology (MAP) computational and discovery platform, Black Diamond is uncovering new ways to functionally assess the mutational landscape of individual oncogenes – to discover and validate new targets and develop novel approaches to creating highly selective therapeutics.

Black Diamond is currently seeking a Principal Scientist, DMPK. Reporting to the VP Preclinical Development, the incumbent will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators as precision cancer medicines. We are looking for a consummate team player seeking a collaborative environment in which to grow their career in drug development. 


  • In partnership with functional/project leaders, set the DMPK strategy and plans for Black Diamond’s discovery and early development programs
  • Establishment and oversight of activities at CROs, including in vitro ADME, PK, bioanalysis and PK/PD modeling
  • Be the functional area representative for DMPK on project teams
  • Design, analyze and interpret preclinical DMPK studies in support of program goals
  • Use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and DDI risk
  • Be a key member of the multidisciplinary team driving pharmacology efforts
  • Author and review study reports and relevant sections of regulatory documents


  • An advanced degree, such as MS and 7+ years of experience, or Ph.D. and 4+ years of experience, with a focus in pharmacokinetics, pharmacology or related discipline
  • Technical depth and a broad understanding of small molecule DMPK, preferably with experience in oncology
  • Extensive experience optimizing and characterizing the ADME properties of small molecule drug candidates, supported by a strong publication record in DMPK sciences. Expertise in the interplay between DMPK parameters, physicochemical and molecular properties
  • Expertise in PK/PD modeling from discovery through early development. Proficient with Phoenix WinNonlin or similar
  • Experience leading DMPK on projects particularly in discovery and early development
  • Operational experience and familiarity with the drug discovery and development process, including external regulatory requirements. Well versed in authoring and reviewing PK sections of regulatory dossiers
  • Proficient in the management of activities at contract research organizations and comfortable working in virtual outsourced model
  • Excellent communication and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors and internal cross-functional, global project teams.

Work Environment:

This job operates in a professional office environment. This role routinely uses standard office equipment.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.