Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.
We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds. The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed efficacy, PK/PD relationships and therapeutic window.
- To identify, develop and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
- To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
- To prepare drug formulations and dosing solutions.
- To carry out all aspects of animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, surgeries, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
- To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
- To maintain detailed laboratory notes, sample records and protocols. To compile, summarize and graph data for presentations.
- The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.
- DEC in Animal Health Technology, BSc., or MSc in biological sciences with at least 2yrs of relevant experience. A background in oncology is a definite asset.
- Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models including tumor implantation and measurement is essential.
- Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), tissue perfusion and blood sampling by multiple routes is essential.
- Experience in pre-clinical drug discovery in an industrial, GLP setting (CRO or other) is an asset.
- Ability to communicate in an open, clear, timely and consistent manner.
- Outstanding organizational skills (lab book, experimental design, etc.).
- Bilingual French/English (spoken and written) is an asset.
- Ability to handle multiple projects and utilize judgement to prioritize tasks.
- Ability to contribute as a team member in a dynamic, fast-paced biotech environment.