Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists. Founded by leading experts at the forefront of DNA damage and repair, cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.
We are seeking an experienced scientist at our Montreal site to assume both a leadership and hands-on role as part of a scientific team responsible for advancing Repare’s drug and target discovery pipelines. The scientist will develop and characterize both immunocompromised and syngeneic mouse models in which to validate novel cancer drug targets using various gene editing technologies. They will be involved in assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds and evaluate drug combinations with targeted agents and immuno-oncology therapeutics.
- To identify and implement clinically relevant rodent tumor models in which to evaluate the in vivo efficacy of novel anticancer compounds and perform target validation studies.
- To implement various genetic knock-out technologies in vivo, in tumor models, for the purposes of target validation.
- To design and execute experiments to evaluate the efficacy, PK/PD relationships and toxicity of candidate drug compounds and drug combinations in the selected in rodent cancer models.
- To evaluate target engagement and mechanism of action from in vivo tumor samples.
- To represent pharmacology at pre-clinical drug development project team meetings.
- To communicate results at project team and other meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
- To maintain detailed laboratory notes and protocols.
- The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
- The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.
- MSc or PhD in biological sciences and minimum of 3 years experience in rodent models of cancer.
- Experience in small animal handling, including drug administration and blood sampling through multiple routes, necropsies, and minor surgery is essential.
- Experience in oncology, immune-oncology, DNA repair and/or chromatin remodelling is essential.
- In vitro techniques such as cell culture, ELISA, western blotting, IHC and FACS analysis are a definite asset.
- Experience in pre-clinical drug discovery, preferably in an industrial setting an asset.
- Ability to communicate in an open, clear, timely and consistent manner.
- Outstanding organizational skills (lab book, experimental design, documentation etc.).
- Ability to handle multiple projects and utilize judgement to prioritize tasks.
- Bilingual French/English (spoken and written) is an asset.
- Ability to contribute as a team member in a dynamic, fast-paced biotech environment.