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Research Scientist – Target Discovery at Repare Therapeutics
Montreal, CA / Quebec, CA

Repare develops novel precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary CRISPR‐enabled genome-wide synthetic lethal (SL) screens for target discovery and patient selection biomarkers with high‐resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair, cancer biology, and high-throughput CRISPR screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We now have an outstanding opportunity available for a motivated Ph.D. or M.Sc.-level research scientist who would like to get in early and grow with the company. The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPRx™ platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery and computational biology teams.

 

RESPONSIBILITIES

  • Become a crucial intellectual and technical leader on our SNIPRx™ target discovery platform
  • Stay up to date on current literature and attend conferences to establish yourself as a key opinion leader within the company
  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
  • Design and execute CRISPR-enabled genome-wide screens
  • Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
  • Apply skill set to identify and fully validate new SL targets
  • Plan and execute experiments to uncover mechanisms underlying SL interactions
  • Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

  • M.Sc. or Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
  • Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
  • Expertise in cell and molecular biology techniques required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact