Research Scientist – Biologics – Conjugation and Analytics at Inception Sciences
San Diego, CA, US

Inception Therapeutics is seeking a creative, motivated and experienced scientist to join the conjugation group. Responsibilities will include protein conjugation and analytics, with the hands-on execution of purification and/or characterization for lead molecules and tool reagents. Expertise in protein conjugation, protein chromatography, and cutting-edge protein analytical techniques will be key to this position.  The candidate will be highly proficient in small molecule conjugation chemistry, including both site-specific and nonspecific conjugation techniques. The ideal candidate will bring creativity and innovative thinking in bridging protein engineering and biology.


Key Responsibilities:


  • Perform all stages of protein conjugation, including conjugation to proteins/antibodies and subsequent purification and analytics
  • Design, assess and troubleshoot purification and analytics protocols
  • Deliver protein conjugates and data analysis packages to project teams in a timely manner
  • Present results regularly at team meetings
  • Perform diligent and timely note keeping and work process tracking


Requirements Qualifications:


  • PhD in molecular biology/biochemistry/organic chemistry or a related discipline and 0-2 years of postdoctoral experience OR BS/MS in related discipline with 8-15 years of industry experience
  • Strong expertise in design, execution, and troubleshooting of protein conjugation and analytics processes, including both site-specific and nonspecific conjugation strategies
  • An understanding of the principals and best practices behind biotherapeutic developability 
  • Experience in protein purification using a variety of methods (e.g. affinity, SEC, IMAC, ion exchange, HIC, and hydroxyapatite chromatography; ultrafiltration), instrumentation (FPLC, HPLC, AKTA) and software (e.g., Unicorn, Chemstation)
  • Strong expertise in characterization of protein preparations using SDS-PAGE/cGE, HPLC (SEC), endotoxin analysis, and Western blot analysis
  • Experience with antibody and biotherapeutic purification and characterization, and a working knowledge of various biotherapeutic modalities
  • Experience with LC/MS characterization of protein samples, especially for antibodies/antibody conjugates and other biotherapeutics would be desirable
  • Experience with data analysis and presentation software
  • Excellent written and oral communication skills
  • The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines
  • The ability to work closely with other group members within teams is essential


Preferred Qualifications:


  • Experience in protein engineering for the design of new antigens, novel biologics formats, and clinical candidates is a plus
  • Knowledge of protein structural biology is a plus


Inception Sciences is a multi-disciplinary discovery engine partnered with Versant Ventures to build and launch transformative new biopharmaceutical companies. We are home to a dynamic team that enjoys working on cutting-edge science to meet unmet medical need across a variety of therapeutic areas. Our integrated chemistry, biology and DMPK expertise and capabilities coupled with a successful track record have enabled Inception to become an established leader in new company creation. We offer competitive compensation and excellent benefits packages, as well as working in a supportive team environment. This position is located in our San Diego office.