Quentis Therapeutics is a preclinical stage biotechnology company that is translating novel biology into new therapeutic approaches to help more cancer patients benefit from immunotherapy. Based on our deep expertise in endoplasmic reticulum (ER) stress biology and the tumor microenvironment, we are pioneering first-in-class ER stress response modulators to boost the immune system’s ability to fight cancer. Our lead program is a first-in-class IRE1α inhibitor. We are pursuing multiple additional ER stress pathway targets in the tumor micro-environment, as well as in other diseases where ER stress plays an important role.
This is a unique opportunity to join an exciting new biotech company in the heart of New York City that has experienced leadership, a strong scientific expertise and significant funding.
Quentis is seeking a highly skilled and motivated scientist with strength in execution of bench science to provide critical support for ongoing and emerging immune-oncology programs. He/she will be accountable for delivering high quality data to be used in project strategy and decision-making.
The successful candidate will perform diverse in vitro and in vivo assays as part of a team to obtain deep mechanistic insights into ER stress biology and evaluate lead molecules generated from internal drug development efforts. Candidates for this role will be driven and enthusiastic self-starters with strong critical thinking skills and a desire to learn. Additionally, the successful candidate must possess outstanding written and verbal communications skills and be able to work efficiently as an individual and in a team setting.
- Design and development of cellular and biochemical assays to be used in the evaluation of potential drug candidates
- Establish functional assays using various techniques including flow cytometry, qPCR, ELISA, luminescence, western blotting, etc.
- Independently plan, execute and analyze well-controlled experiments
- Organize, analyze and clearly communicate results to team members
- Independently propose new experimental approaches and next steps
- Keep well documented electronic lab notebook
- Bachelors or Masters degree or equivalent with 5+ years work experience in Immunology, Oncology, or related research
- Ability to design, execute and interpret experiments with minimal guidance
- A passion for scientific discovery and an ability to succeed in a biotech/entrepreneurial fast-paced drug-discovery environment
- Experience using molecular biology and biochemical techniques to evaluate intracellular signaling or experience with mouse tumor models including compound dosing preferred
- Strength in collaboration; able to work effectively across teams
- Excellent communication, organizational and documentation skills